COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF CARBAMAZEPINE AND GABAPENTIN IN THE MANAGEMENT OF TRIGEMINAL NEURALGIA

JPUMHS;2023:13:04,67-72. http://doi.org/10.46536/jpumhs/2023/13.04.473

Abstract

Abstract Objective: This study's purpose was to evaluate the effectiveness of carbamazepine and gabapentin for the treatment of “Trigeminal Neuralgia”. Study design: A prospective randomized clinical trial. Study period: Six-month study was conducted from 15 March 2023 to 15 September 2023. Study settings: The study was conducted in the “Department of Oral Medicine”, Faculty of Dentistry and Allied Sciences, Isra University Hyderabad Sindh. Material and method: A total of 60 clinically diagnosed patients of Trigeminal Neuralgia were enrolled after meeting inclusive criteria. Patients were diagnosed by clinical examination and a detailed history of pain. Doubtful patients were evaluated by radiographic examination. The patient's demographical features were recorded in the MS Excel worksheet (2013). Patients were randomly separated into two groups, A and B. Group A patients were treated with carbamazepine whereas Group B patients received Gabapentin. All the patients were advised to follow up on the “7th day”, “15th day”, and 1-month period to evaluate the drug response. Data were analyzed through the SPSS 20 version. Results: A total of 60 trigeminal neuralgia patients were enrolled, 23 (38.3%) out of 60 were male and 37 (61.7%) were female patients. The average age of male participants was 53.61 years and the mean age of female participants was 52.12 years. 31(51.7%). A total of 13 male and 21 female patients had pain in the right side of the face, whereas 10 males and 16 females had pain in the left side of the face. TN was most commonly found in the Maxillary region as compared to the Mandibular area. The study reported an important pain decrease in Group B as likened to Group A.Conclusion: In our research study it was concluded that both drug carbamazepine and gabapentin can be used to treat Trigeminal neuralgia patients, but in this research study we found Gabapentin can be proven effective when compared to carbamazepine in pain relief and management of TN.