Impact of li oprotein and Basal Metabolic Index on Pre-eclamptic Women

Abstract

OBJECTIVE: The pre-eclampsia (PE) is common hypertensive and life threatening disorder during pregnancy. Increase concentration of Lipoprotein and Increase basal metabolic index (BMI) are the risk factors for developing per-eclampsia. METHODOLGY: A cross sectional, comparative study, conducted in Biochemistry department Liaquat University of Medical & Health Sciences (LUMHS) Jamshoro after approval from Ethical Research committee of LUMHS. Total 100 pregnant women were recruited out of which 50 females were normal healthy women as control, 50 were obese pre-eclamptic women as cases. The subjects were conducted from department of Obstetrics & Gynecology Liaquat University Hospital Jamshoro / Hyderabad, during the period of February 2016 to October 2017. The sampling technique was random sampling. Informed written consent were taken from all participant and collected the sample after taking obstetric history, anthropometric, clinical data and collecting blood sample from volunteers. The lipid profile was evaluated on spectrophotometer and data was entered on Microsoft Excel and SPSS 16.0 (IBM, incorporation, USA). Student t-test was applied for analysis of continuous variables.

RESULTS: Total cholesterol, triacylglycerol (TAGs), High Density lipoprotein (HDL), low density lipoprotein (LDL) and Very low density lipoprotein (VLDL) in pre-eclamptic patients (p<0.05) as compared with control group respectively. The BMI was increases with significant difference of (p<0.05) respectively. CONCLUSION: The results showed that lipoproteins were increased significantly in pre-eclamptic subjects and high risk factors of developing pre-eclampsia. Early measures can decrease morbidity and mortality in pregnant women.