To Evaluate The Outcome Of Metformin With And Without Clomiphene Citrate In Polycystic Ovarain Disease (PCOD) At Tertairy Care Hospital

Abstract

Introduction:-Polycystic ovarian disorder (PCOD) is the steady endocrine issue affecting 4-12' o of women. Its diagnosis is done on the basis of oligo-ovulation/ anovulation, menstrual disturbances, hyperandrogenism and ultrasound findngs. Women with this disease are more insulin resistant. Maternal weight can soundly affect origination. Studies have announced the higher paces of preterm birth, premature delivery and low birth weight in babies destined to hefty versus ordinary weight ladies with PCOD.

Objective: - To determine the outcome of metformin with and without clomiphene Study design: - Cross sectional study Place of study: Department of Gyn/Obs Unit 2 PMCH Nawabshah Material and methods:- This study wasdone in Department of Gyn/Obs Unit 2 at PMCH Nawabshah. It is a cross sectional study done from February 2016 to July 2017. Only non pregnant ladies from 23 years to 35 years were selected for the study having polycystic ovarian disease diagnosed after history, clinical examination and imaging investigations.Results: - Total 37 patients were taken for the study. Metformin was given to 18 (48.649c) patients with Clomiphene citrate in group A and 19 (51.359c) without it in group B. Group A showed ovulation among 16 (88.889a) patients and pregnancy in 17 (94.449a). Whereas in Group B showed ovulation in 14 (73.68' o) and pregnancy in 15 (78.949a) patients. Conclusion: - It is summed up that metformin with clomiphene citrate showed enormous positive results with increased ovulation improvement and pregnancy in patients suffering from PCOD.