ANALYSIS OF VITAMIN-D INTAKE ON LIPID PROFILE IN PATIENTS WITH TYPE-II DIABETES MELLITUS TAKING METFORMIN.

Abstract

Introduction: vitamin D deficiency if a global issue. Objective: To analyze role of vitamin-D (Vit.D) supplementation on the lipid profile of individuals having type-II diabetes mellitus, taking metformin. Methods: This observational and interventional study was conducted inthe Pharmacology department in cooperation with Sindh Institute of Endocrinology & Diabetes (SIED) affiliated with Liaquat University of Medical and Health Sciences, Jamshoro from 1stMarch to 31stAugust 2018.One hundred and forty diagnosed cases of diabetes type-2 were selected under strict inclusion criteria. These were alienated into 2 groups of seventy each (A & B). Group-A acted as control while group B was given Vit D supplement 800 IU per day daily for three months. Vit.D level & lipid profile were estimated at base line and after 3 months. Results: After 3 months of Vit. D supplementation in group B, lipid profile parameters including total cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL), and triglycerides (TG) revealed a significant decrease as compared to group A. No any major variation in HDL levels of group-B as compared to group-A was noticed. Level of Vit.D revealed a significant increase after 3 months in group-B in relation to group-A. Conclusion: Vitamin-D levels in blood are increased by vitamin-D supplementation. Blood Vit.Dconcentrationis enhanced by increased intake of VitD, with improvement in levels of serum total cholesterol (TC), TG and LDL with no beneficial effect on serum HDL.