Precancerous Lesions in Routine Cholecystectomy Specimens

Abstract

 Objective: To determine the frequency ofprecanccrous lesions in routine cholecystectomy specimens. Study Design: Observational, descriptive study. Place & Duration: Department of Histopathology. Pakistan Naval Ship (PNS) Shifa Karachi. from January to December 2010. Material and Methods: A total of 292 Cholecystectomy specimens were included in this study. After gross examination the representative sections were taken, processed and embedded in paraffin as per standard procedure, 4p thick paraffin sections were cut and stained with hernatoxylin and eosin followed by microscopic examination. Documentation including the hospital identification number, laboratory number, date of receipt of the specimen, patient's age /sex duration of disease, pre operative diagnosis, microscopic description and diagnosis were noted down on a proforma. Data was analyzed on Statistical Package for Social Sciences (SPSS ) version 16.0. Results: Majority of the patients 33,22% (n=97) were recorded between 41-50 years of age, 27.05% (n=79) were found with 51-60 years, 23.29% (n=68) with 31-40 years while 16.440. (n=48) was found between 20-30 years of age. The mean age was recorded as 42.7 with 1.24 S.D. Among 292 cases 84.25% (n=246) were female and 15.75% (n=46) were male. The status of precancerous lesion(s) squamous metaplastic lesions were found in 13,01% (n=38), metaplastic intestinal in 8.92% (n=26), dysplastic in 7.53% (n=22) and other non-precancerous changes were found in 70.5% (n=206). Majority of the patients 51.16% (n=44) having history of 1-2 years duration of the disease, 23.25°A) (n=20) with 2-3 years while 25.59% (n=22) with >3 years,Chronic cholecystitis and cholelithiasis was found in all (100%) cases, with multiple small stones were found in 66.27/0 (n=57) while 33.73% (n=29) cases having solitary stone. Conclusion: Identification of metaplastic changes of gallbladder carcinoma are important and suggested that every cholecystectomy specimen may be sent to the histopathologist and not be ignored and considered useless.