Glucose Lowering Potential of Cinnamomum Cassia Bark Extract in Induced Diabetic Wistar Albino Rat Model

Abstract

Objective: To determine the effects of Cinnamomum cassia bark extract (CCBE) on -cell of islets of Langerhans as evaluated by serum insulin and blood glucose in alloxan-induced diabetic rat model.

Study Design: Experimental study

Duration of Study: December 2013 to October 2014

Material and Methods:  Forty Wistar albino rats of both genders were selected according to inclusion and exclusion criteria and were divided into 4 groups. Diabetes mellitus (DM) was inducted by giving single intra-peritoneal administration of alloxan monohydrate 120mg/kg body weight. CCBE was given for 6 weeks orally. Blood glucose and serum insulin were measured by standard laboratory methods. Data was analyzed on SPSS 21.0. A significant p-value was defined as =0.05.

Results: CCBE showed statistically significant glucose lowering effect. A rise in serum insulin was observed in CCBE treated diabetic rats in particular the rats which received high dose (0.6 grams).

Conclusion: Cinnamomum cassia bark extract showed glucose lowering potential and insulin secretion augmenting activity.